反应详情

温度

65 °C

To 5-methylisophthalic acid (Aldrich, 5 g, 27.7) in MeOH (37.5 ml)/THF (112.5 ml), conc. H2SO4 (1.25 ml) was added and stirred at 65° C. for 8 h. Reaction mixture was cooled to room temperature and solvent removed. Then reaction mixture was diluted with water and extracted with ethylacetate. Crude residue was column chromatographed to yield 2.5 g of 3-(methoxycarbonyl)-5-methylbenzoic acid as a white solid.

1. customReaction mixture
2. temperaturewas cooled to room temperature
3. customsolvent removed
4. customThen reaction mixture
5. extractionextracted with ethylacetate
6. customchromatographed