Trifluoroacetic anhydride → HCID 68671133, compound

HRID 2071157Notes

Reaction equation

HRID 2071157 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N+:5]([O-])=[C:4]([CH3:10])[CH:3]=1.[F:11][C:12]([F:23])([F:22])[C:13]([O:15]C(=O)C(F)(F)F)=[O:14]>C(Cl)Cl>[F:11][C:12]([F:23])([F:22])[C:13]([O:15][CH2:8][C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[C:4]([CH3:10])[N:5]=1)=[O:14]

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 124930354-Bromo-2,6-dimethylpyridine 1-oxide

Product 1

HCID 68671133HCID 68671133, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2.14 g 4-bromo-2,6-dimethylpyridine 1-oxide in 10 mL of CH2Cl2 was added 7.4 mL of trifluoroacetic anhydride. After 20 h, the solution was concentrated, and the crude product was purified by flash silica gel chromatography (5% MeOH/CHCl3) to give 1.93 g of (4-bromo-6-methylpyridin-2-yl)methyl 2,2,2-trifluoroacetate with some impurity.

Workup

  1. concentrationthe solution was concentrated
  2. customthe crude product was purified by flash silica gel chromatography (5% MeOH/CHCl3)

Sources & evidence

ORD record
ord-01a30e54931a4a6b83cc6b3eade5a5ad
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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