HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2071179Generated: October 31, 2026
3-(aminomethyl)-N,N-dimethylaniline → HCID 59570849, compound
https://huagongshe.com/reaction/2071179
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(aminomethyl)-N,N-dimethylaniline | HCID 2760938 | — |
| Reactant | (2S,3S)-(-)-3-tert-Butoxycarbonylamino-1,2-epoxy-4-phenylbutane | HCID 9903372 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59570849 | HCID 59570849 | — |
Reaction Steps
3-(aminomethyl)-N,N-dimethylaniline (1.2 eq) was dissolved in the minimum amount of anhydrous CH2Cl2 under Ar, followed by the addition of tert-butyl (S)-1-((S)-oxiran-2-yl)-2-phenylethylcarbamate (1 eq) with stirring. Anhydrous CH2Cl2 was added dropwise until all of the epoxide had dissolved. The reaction was heated to 50° C. After heating overnight all of the solvent was gone leaving a solid in the flask. Purification via flash chromatography yielded tert-butyl (2S,3R)-4-(3-(dimethylamino)benzylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299267B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-147ae0dc235645b4b025e4a6bf33e454 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
