4-Chlorophenyl Isocyanate → HCID 21413417, compound

Participants

Reaction Steps

A solution of 17.0 g. (0.11 mol.) of 4-chlorophenyl-isocyanate in 71 ml. of tetrahydrofuran is added at room temperature to the stirred suspension of 12.7 g. (0.1 mol.) of 2-methyl-5-nitroimidazole and 0.5 g. of triethylamine in 70 ml. of tetrahydrofuran. A slightly exothermic reaction sets in, which terminates after 4 hours of stirring. The separated product is filtered off, washed with toluene and dried. 25 g. (89.5%) of 1-(4-chlorophenyl)-carbamoyl-2-methyl-5-nitroimidazole are obtained. The white, crystalline substance melts above 240° C.

Provenance & Evidence