Methanol → HCID 21413341, compound

HRID 2071304Notes

Reaction equation

HRID 2071304 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[N:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:10]3[CH:9]([OH:18])[N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1.S(=O)(=O)(O)O.[CH3:31]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[N:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:10]3[CH:9]([O:18][CH3:31])[N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 21413348HCID 21413348, compound

Product 1

HCID 21413341HCID 21413341, compound

Procedure

To a solution of 8-chloro-4-hydroxy-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide (3/2 hydrate) in methanol is added a small amount of concentrated sulfuric acid, and the mixture is treated in the same manner as that of Example 3 to give 8-chloro-4-methoxy-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide as crystals (1/3 hydrate). This product is identical with the product in Example 3 with respect to melting point and infrared absorption spectrum.

Workup

  1. additionthe mixture is treated in the same manner as that of Example 3

Sources & evidence

ORD record
ord-eb15183cd1a64d21b2aa0bf78aff9dcc
Source dataset
uspto-grants-1977_09
Patent number
US04046772

Reaction notes

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