HCID 21413155, compound → 2-Chloro-3-(4-chlorophenyl)pyrazine

HRID 2071309Notes

Reaction equation

HRID 2071309 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](O)=[N:10][CH:11]=[CH:12][N:13]=2)=[CH:4][CH:3]=1.CC(C1C(C2C=CC([Cl:39])=CC=2)=NC=CN=1)(C(OCC)=O)C(OCC)=O.CC(C1C(C2C=CC(Cl)=CC=2)=NC=CN=1)C(OCC)=O.CC(C1C(C2C=CC(Cl)=CC=2)=NC=CN=1)C(O)=O.CC(C1C(C2C=CC(Cl)=CC=2)=NC=CN=1)C(N)=O>>[Cl:39][C:9]1[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[N:13][CH:12]=[CH:11][N:10]=1

Participants

6

Reactant 5

HCID 21413155HCID 21413155, compoundHCID 21413205alpha-Methyl-3-(p-chlorophenyl)pyrazineacetamideHCID 21413210Diethyl alpha-methyl-3-(p-chlorophenyl)pyrazinylmalonateHCID 21413211Ethyl alpha-methyl-3-(p-chlorophenyl)pyrazineacetateHCID 178517835HCID 178517835, compound

Product 1

HCID 131998892-Chloro-3-(4-chlorophenyl)pyrazine

Procedure

2-Chloro-3-(p-chlorophenyl)pyrazine is prepared by the method of Karmas and Spoerri. (loc. cit.), using 3-(p-chlorophenyl)pyrazinol as the starting material. Starting with this material and using the procedures of Examples V, VI, IX, and XI, the products obtained are diethyl α-methyl-3-(p-chlorophenyl)pyrazinylmalonate, ethyl α-methyl-3-(p-chlorophenyl)pyrazineacetate, α-methyl-3-(p-chlorophenyl)pyrazineacetic acid, and α-methyl-3-(p-chlorophenyl)pyrazineacetamide.

Workup

  1. customthe products obtained

Sources & evidence

ORD record
ord-d0a69c353d944da595f2df62b3ae3b17
Source dataset
uspto-grants-1977_09
Patent number
US04046763

Reaction notes

Loading…