反应详情

A current of hydrochloric acid gas was passed with stirring through a solution of 30 g of 2-propyl-thiazole-5-carboxylic acid in 400 ml of absolute ethanol overnight and the ethanol was then evaporated off. The oily residue was taken up in ether containing 10% of potassium carbonate and the mixture was extracted with ether. The ether extracts were washed with water until a pH of 6 was obtained and the resulting yellow oil was purified by distillation to obtain 31.2 g of ethyl 2-propyl-thiazole-5-carboxylate with a boiling point of 139°-140° C. at 16 mmHg.

1. customthe ethanol was then evaporated off
2. extractionthe mixture was extracted with ether
3. washThe ether extracts were washed with water until a pH of 6
4. customwas obtained
5. distillationthe resulting yellow oil was purified by distillation