Water → HCID 178483587, compound

HRID 2071432Notes

Reaction equation

HRID 2071432 reaction equation
[CH:1]1([CH2:7][S:8][C:9]2[CH:22]=[CH:21][C:12]3[NH:13][C:14]([NH:16][C:17](=[O:20])[O:18][CH3:19])=[N:15][C:11]=3[CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26]CO.O>C1(C)C=CC=CC=1>[CH:5]1[CH2:4][CH2:3][CH2:2][CH:1]([CH2:7][S:8][C:9]2[CH:22]=[CH:21][C:12]3[NH:13][C:14]([NH:16][C:17](=[O:20])[O:18][CH2:19][CH2:26][CH2:25][N:24]([CH3:29])[CH3:23])=[N:15][C:11]=3[CH:10]=2)[CH:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 766463-(Dimethylamino)-1-propanolHCID 178502042HCID 178502042, compound

Product 1

HCID 178483587HCID 178483587, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 0.01 mole of the methyl ester of Example 4 and 0.02 mole of 3-dimethylamino-1-propanol is refluxed in 20 ml of toluene until all the H2O present has been azeotroped off. The heating mantle is removed and 0.25 g of aluminum isopropoxide is added. The mixture is then refluxed overnight. After cooling the solid present is filtered off, washed with water and crystallized.

Workup

  1. custompresent has been azeotroped off
  2. customThe heating mantle is removed
  3. addition0.25 g of aluminum isopropoxide is added
  4. temperatureThe mixture is then refluxed overnight
  5. temperatureAfter cooling the solid present
  6. filtrationis filtered off
  7. washwashed with water
  8. customcrystallized

Sources & evidence

ORD record
ord-1ee3b2bf1aeb41b4b2c586ca503e85b6
Source dataset
uspto-grants-1977_09
Patent number
US04046908

Reaction notes

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