反应详情

The 8-amino product of Example 3 (free base) (3 g.) was dissolved in acetonitrile (30 ml.) and the solution treated with methylisothiocyanate (1.35 g.) and heated at reflux for 2 hours. The solvent was removed in vacuo and the residual solid recrystallised from absolute ethanol to give the title compound as colourless needles (3 g.) m.p. 113° C.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. customThe solvent was removed in vacuo
4. customthe residual solid recrystallised from absolute ethanol