HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 8-Methylthiocarbamoylamino-3-methyl-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 8-Amino-3-methyl-5,6,7,8-tetrahydroquinoline dihydrochloride | HCID 12358221 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-Methylthiocarbamoylamino-3-methyl-5,6,7,8-tetrahydroquinoline | HCID 12358211 | 99.9% |
Reaction Steps
The 8-amino product of Example 3 (free base) (3 g.) was dissolved in acetonitrile (30 ml.) and the solution treated with methylisothiocyanate (1.35 g.) and heated at reflux for 2 hours. The solvent was removed in vacuo and the residual solid recrystallised from absolute ethanol to give the title compound as colourless needles (3 g.) m.p. 113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04048175 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-d879ebb376dc4865a6d28e3ab5da9fdf |
| Source note | uspto-grants-1977_09 |