HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methylamino)pentyloxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 8-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849569 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methylamino)pentyloxy)-2H-chromen-2-one | HCID 59347967 | — |
Reaction Steps
The title compound was prepared from methylamine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 27. 1H NMR (400 MHz, DMSO-d6): δ 8.44 (br s, 2H), 8.33 (s, 2H), 7.78 (d, 1H), 6.92 (d, 1H), 3.94 (t, 2H), 3.85 (s, 1H), 3.84 (s, 3H), 2.93 (t, 2H), 2.53 (s, 3H), 1.82-1.56 (m, 6H); MS (ESI): 452.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d0ded153abd24151bba36070bc54ff6d |
| Source note | uspto-grants-2010_06 |