反应详情

温度

80 °C

To a solution of 2-chloro-3,4-dihydro-3,3-dimethyl-4-phenylquinolin-4-ol (1.0g., 0.0035 mole) in dry dioxan (15 ml.) and triethylamine (1 ml.) was added 4-benzamidopiperidine (0.67 g., 0.0035 mole). After heating at 80° C for 41/2 hours, the reaction mixture was cooled, a small amount of solid was filtered off and the filtrate evaporated down to a residue. Trituration with hexane yielded the title compound as the crude free base (m.p. 78° - 81° C). The hydrobromide (1.05g., m.p. 166° - 168° C) was obtained as the monohydrate on crystallisation from isopropyl alcohol. [Found: C, 62.75; H, 6.2; N, 7.3% C29H31N3O2H2O HBr requires: C, 63.0; H, 6.2; N, 7.6%].

1. temperaturethe reaction mixture was cooled
2. filtrationa small amount of solid was filtered off
3. customthe filtrate evaporated down to a residue