Potassium Carbonate → HCID 53770721, compound

HRID 2071663Notes

Reaction equation

HRID 2071663 reaction equation
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[CH2:15][CH2:14][CH:13]([CH:16]=[CH:17][CH:18]([OH:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[O:12]1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:24][CH:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:17]=[CH:16][CH:13]1[O:12][CH:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 53980569HCID 53980569, compound

Product 1

HCID 53770721HCID 53770721, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

IV (1.77 g, 0.00500 mole), methanol 20 ml), and 20% aqueous potassium carbonate (10 ml) were stirred and heated under reflux for 90 minutes. The methanol was removed from a water bath (60° C, 100 mm Hg). The residue was diluted with water (25 ml) and washed with ether (25 ml). The resulting clear solution was acidified to pH 5-6 with acetic acid. The resulting emulsion was extracted with ether (25 + 25 ml). The combined ethereal extracts were dried over sodium sulfate and evaporated from a water bath (60° C, 1 mm Hg) to give 1.60 g (94%) of V as a colourless oil, nD25 1.4778.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 90 minutes
  3. customThe methanol was removed from a water bath (60° C, 100 mm Hg)
  4. additionThe residue was diluted with water (25 ml)
  5. washwashed with ether (25 ml)
  6. extractionThe resulting emulsion was extracted with ether (25 + 25 ml)
  7. dry with materialThe combined ethereal extracts were dried over sodium sulfate
  8. customevaporated from a water bath (60° C, 1 mm Hg)
  9. customto give 1.60 g (94%) of V as a colourless oil

Sources & evidence

ORD record
ord-7219cb8dd1b24a13a34a5a76605c8b99
Source dataset
uspto-grants-1977_09
Patent number
US04048198

Reaction notes

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