Potassium Carbonate → HCID 21412029, compound

Participants

Reaction Steps

VIII (1.77 g, 0.00500 mole), methanol (20 ml), and 20% aqueous potassium carbonate (10 ml) were stirred and heated under reflux for 2.5 hours. The methanol was removed fron a water bath (60° C, 100 mm Hg). The residue was diluted with water (25 ml) and washed with ether (25 ml). The resulting clear solution was acidified to pH 5-6 with acetic acid. The emulsion being formed was extracted with ether (25 + 25 ml). The combined ethereal extracts were dried over sodium sulfate and evaporated from a water bath (60° C, 1 mm Hg). The yellowish, oily residue of IX (1.60 g, 94%) solidified by standing. M.p. 26°-28° C, nD25 1.4673.

Provenance & Evidence