Tetrafluoro-m-phenylenediamine dihydrochloride → 3-(2-Imidazolyl)propylguanidine sulphate monohydrate

HRID 2071772Notes

Reaction equation

HRID 2071772 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:6][CH:7]=[CH:8][N:9]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[S:24]([O-:28])([O-:27])(=[O:26])=[O:25].CS[C:31]([NH2:33])=[NH2+:32].CSC(N)=[NH2+]>O>[OH2:25].[S:24]([OH:28])([OH:27])(=[O:26])=[O:25].[NH:6]1[CH:7]=[CH:8][N:9]=[C:5]1[CH2:4][CH2:3][CH2:2][NH:1][C:31]([NH2:33])=[NH:32]

Participants

5

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 6604939S-methyl isothiourea hemisulfateHCID 132907973-(1H-Imidazol-2-yl)propan-1-amine

Product 1

HCID 1785127913-(2-Imidazolyl)propylguanidine sulphate monohydrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-(3-aminopropyl)imidazole, prepared from its dihydrochloride (0.9 g) by means of an ion-exchange resin (OH-1), and S-methylthiouronium sulphate (1.26 g) in water (20 ml) is heated under reflux for 18 hours. The product, isolated in a manner similar to that described in Example 1, is recrystallized from aqueous ethanol yielding 3-(2-imidazolyl)propylguanidine sulphate monohydrate, m.p. 260°-262° C. (dec.).

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 18 hours
  3. customThe product, isolated in a manner similar to
  4. customis recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-28aaf3c386ee4e8f96d9b794fe3019b8
Source dataset
uspto-grants-1977_09
Patent number
US04048319

Reaction notes

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