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Tetrafluoro-m-phenylenediamine dihydrochloride → 3-(2-Imidazolyl)propylguanidine sulphate monohydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 反応物 | S-methyl isothiourea hemisulfate | HCID 6604939 | — |
| 反応物 | 3-(1H-Imidazol-2-yl)propan-1-amine | HCID 13290797 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(2-Imidazolyl)propylguanidine sulphate monohydrate | HCID 178512791 | — |
反応手順
A solution of 2-(3-aminopropyl)imidazole, prepared from its dihydrochloride (0.9 g) by means of an ion-exchange resin (OH-1), and S-methylthiouronium sulphate (1.26 g) in water (20 ml) is heated under reflux for 18 hours. The product, isolated in a manner similar to that described in Example 1, is recrystallized from aqueous ethanol yielding 3-(2-imidazolyl)propylguanidine sulphate monohydrate, m.p. 260°-262° C. (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04048319 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-28aaf3c386ee4e8f96d9b794fe3019b8 |
| 出典メモ | uspto-grants-1977_09 |