2-Amino-2-methyl-1-propanol → HCID 21412654, compound

Participants

Reaction Steps

A solution of 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl) propionic acid (1 g.) and 2-amino-2-methylpropan-1-ol (1 ml.) in xylene (20 ml.) was stirred under reflux for 3 days. The solvent was distilled and the solid residue was recrystallised from aqueous methanol to give 2-[1-(2',4'-difluoro-2-hydroxy-4-biphenylyl)ethyl]-4,4-dimethyl-2-oxazoline, m.p. 188°-194° C. (decomposes).

Provenance & Evidence