2-Amino-2-methyl-1-propanol → HCID 21412654, compound

HRID 2071793Notes

Reaction equation

HRID 2071793 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([OH:18])=O)=[CH:11][C:10]=1[OH:20].[NH2:21][C:22]([CH3:26])([CH3:25])[CH2:23]O>C1(C)C(C)=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:16]2[O:18][CH2:23][C:22]([CH3:26])([CH3:25])[N:21]=2)[CH3:19])=[CH:11][C:10]=1[OH:20]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 21320548HCID 21320548, compound

Product 1

HCID 21412654HCID 21412654, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl) propionic acid (1 g.) and 2-amino-2-methylpropan-1-ol (1 ml.) in xylene (20 ml.) was stirred under reflux for 3 days. The solvent was distilled and the solid residue was recrystallised from aqueous methanol to give 2-[1-(2',4'-difluoro-2-hydroxy-4-biphenylyl)ethyl]-4,4-dimethyl-2-oxazoline, m.p. 188°-194° C. (decomposes).

Workup

  1. temperatureunder reflux for 3 days
  2. distillationThe solvent was distilled
  3. customthe solid residue was recrystallised from aqueous methanol

Sources & evidence

ORD record
ord-e4b2124ad6114480a81385c6c9fd7f5f
Source dataset
uspto-grants-1977_09
Patent number
US04048332

Reaction notes

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