Diethyl Ether → p-Chlorophenacyl bromide

To a stirred, cooled solution of 4-chloroacetophenone (100 g, 0.65 mole), anhydrous ether (650 ml) and dioxane (325 ml) was added bromine (35 ml, 0.65 mole) dropwise over a period of 1.25 hours, keeping the temperature at 20° C. (±5° C.). The solution was then washed with water (3 × 1 l). The collected ether layer was dried over magnesium sulfate and the ether solution was evaporated under reduced pressure to give a solid. The solid was washed with water, collected by filtration, and air-dried to give the α-bromo-4-chloroacetophenone.

1. customat 20° C.
2. custom(±5° C.)
3. washThe solution was then washed with water (3 × 1 l)
4. dry with materialThe collected ether layer was dried over magnesium sulfate
5. customthe ether solution was evaporated under reduced pressure
6. customto give a solid
7. washThe solid was washed with water
8. filtrationcollected by filtration
9. customair-dried

ORD record

ord-675651b12dee4e628a75a408a3b2658b

Source dataset

uspto-grants-1977_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04049650