Potassium bisulfate → Praziquanamine

HRID 2071897Notes

Reaction equation

HRID 2071897 reaction equation
C([N:9]1[CH2:22][C:21](=[O:23])[N:12]2[CH2:13][CH2:14][C:15]3[C:20]([CH:11]2[CH2:10]1)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=O)C1C=CC=CC=1.S([O-])(O)(=O)=O.[K+]>>[O:23]=[C:21]1[N:12]2[CH2:13][CH2:14][C:15]3[C:20]([CH:11]2[CH2:10][NH:9][CH2:22]1)=[CH:19][CH:18]=[CH:17][CH:16]=3

Participants

3

Reactant 2

HCID 516920Potassium bisulfateHCID 31049102-Benzoyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Product 1

HCID 6453168PraziquanamineYield 91%

Procedure

g. of 2-benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is boiled with 20 ml. concentrated potassium hydrogen sulfate solution for 48 hours. The solution is subsequently extracted with chloroform, and the organic phase is dried with sodium sulfate and evaporated. 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline of m.p. 119°-120° C. is obtained in a yield of 91%.

Workup

  1. extractionThe solution is subsequently extracted with chloroform
  2. dry with materialthe organic phase is dried with sodium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-346ce5a6f3c94f20a2a639fa7b7c1043
Source dataset
uspto-grants-1977_09
Patent number
US04049659

Reaction notes

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