HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium bisulfate → Praziquanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | 2-Benzoyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one | HCID 3104910 | — |
| Product | Praziquanamine | HCID 6453168 | 91% |
Reaction Steps
g. of 2-benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is boiled with 20 ml. concentrated potassium hydrogen sulfate solution for 48 hours. The solution is subsequently extracted with chloroform, and the organic phase is dried with sodium sulfate and evaporated. 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline of m.p. 119°-120° C. is obtained in a yield of 91%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04049659 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-346ce5a6f3c94f20a2a639fa7b7c1043 |
| Source note | uspto-grants-1977_09 |