Guanidine → 2-((Thiazol-5-ylmethyl)thio)ethanamine
反応式
NC(N)=N.NC(N)=S.N[C:10]1[S:11][C:12]([CH2:15][S:16][CH2:17][CH2:18][NH2:19])=[CH:13][N:14]=1.C(ON=O)C>>[NH2:19][CH2:18][CH2:17][S:16][CH2:15][C:12]1[S:11][CH:10]=[N:14][CH:13]=1参加物
実験手順
Conversion of the compounds of formula II to the pharmacologically active guanidine and thiourea products is accomplished in a variety of ways. When R2 is --SCH2CH2NH2, the 2-amino group of the 2-amino-5-(2-aminoethyl)thiomethylthiazole is removed, for example by reaction with ethylnitrite, to give the corresponding 5-(2-aminoethyl)thiomethylthiazole compound which is then treated with methyl isothiocyanate to give the corresponding N-methyl-N'-[2-(4-R1 -thiazolylmethylthio)ethyl]thioureas. Reaction of the same 5-(2-aminoethyl)thiomethylthiazole compound with N-cyano-N',S-dimethylisothiourea gives the corresponding N-cyano-N'-methyl-N"-[2-(4-R1 -thiazolylmethylthio)ethyl]guanidines. The guanidine products are also prepared by reaction of the 5-(2-aminoethyl)thiomethylthiazole with dimethyl-N-cyanoimidodithiocarbonate and subsequently reacting the resulting N-cyano-N'-[2-(4-R1 -thiazolylmethylthio)ethyl]-S-methylisothiourea with methylamine.
出典と根拠
- ORDレコード
- ord-6838ee9de1b1482eb0e4047a04d6cbb0
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04049669
反応ノート
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