反应详情

A solution of 3.2 g. of 2-amino-5-methoxymethyl-4-methylthiazole in 100 ml. of dry tetrahydrofuran was brought to reflux and a solution of 6 g. of ethylnitrite in 75 ml. of dry tetrahydrofuran was added dropwise to the refluxing solution. After refluxing an additional 5 hours, the mixture was cooled and evaporated to give an oil. The oil was extracted into hexane and the hexane solution was evaporated to dryness to give 5-methoxymethyl-4-methylthiazole.

1. temperatureto reflux
2. temperatureAfter refluxing an additional 5 hours
3. temperaturethe mixture was cooled
4. customevaporated
5. customto give an oil
6. extractionThe oil was extracted into hexane
7. customthe hexane solution was evaporated to dryness