Cysteamine Hydrochloride → 2-[[(4-Methyl-5-thiazolyl)methyl]thio]ethanamine

HRID 2071924Notes

Reaction equation

HRID 2071924 reaction equation
Cl.CO[CH2:4][C:5]1[S:9][CH:8]=[N:7][C:6]=1[CH3:10].Cl.[NH2:12][CH2:13][CH2:14][SH:15]>C(O)(=O)C>[NH2:12][CH2:13][CH2:14][S:15][CH2:4][C:5]1[S:9][CH:8]=[N:7][C:6]=1[CH3:10]

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 12778175HCID 12778175, compound

Product 1

HCID 214100102-[[(4-Methyl-5-thiazolyl)methyl]thio]ethanamine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5-Methoxymethyl-4-methylthiazole hydrochloride (1.04 g.) and 0.66 g. of cysteamine hydrochoride in 5.5 ml. of acetic acid was refluxed for 24 hours. The mixture was concentrated and the residue was dissolved in water. The aqueous solution was neutralized with sodium hydroxide and extracted with chloroform. The extract was dried (MgSO4) and evaporated to dryness to give 5-(2-aminoethyl)thiomethyl-4-methylthiazole.

Workup

  1. concentrationThe mixture was concentrated
  2. dissolutionthe residue was dissolved in water
  3. extractionextracted with chloroform
  4. dry with materialThe extract was dried (MgSO4)
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-aa62f3223d8747d3b694af3b418b2ba7
Source dataset
uspto-grants-1977_09
Patent number
US04049669

Reaction notes

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