Cysteamine Hydrochloride → 2-[[(4-Methyl-5-thiazolyl)methyl]thio]ethanamine

Participants

Reaction Steps

5-Methoxymethyl-4-methylthiazole hydrochloride (1.04 g.) and 0.66 g. of cysteamine hydrochoride in 5.5 ml. of acetic acid was refluxed for 24 hours. The mixture was concentrated and the residue was dissolved in water. The aqueous solution was neutralized with sodium hydroxide and extracted with chloroform. The extract was dried (MgSO4) and evaporated to dryness to give 5-(2-aminoethyl)thiomethyl-4-methylthiazole.

Provenance & Evidence