Methyl isothiocyanate → HCID 21410014, compound

Participants

Reaction Steps

Potassium carbonate (7.75 g.) is added to a solution of 15.6 g. of 5-(2-aminoethyl)thiomethyl-4-methylthiazole dihydrochloride in 120 ml. of water. The solution is maintained at ambient temperature for 15 minutes and 5.15 g. of methyl isothiocyanate is added. After refluxing for 1.5 hours, the solution is cooled and the product is collected by filtration to give N-methyl-N'-[2-(4-methyl-5-thiazolylmethylthio)ethyl]-thiourea.

Provenance & Evidence