Methyl isothiocyanate → HCID 21410014, compound

HRID 2071926Notes

Reaction equation

HRID 2071926 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl.Cl.[NH2:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[S:18][CH:17]=[N:16][C:15]=1[CH3:19].[CH3:20][N:21]=[C:22]=[S:23]>O>[CH3:20][NH:21][C:22]([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[S:18][CH:17]=[N:16][C:15]=1[CH3:19])=[S:23]

Participants

5

Reactant 3

HCID 11167Methyl isothiocyanateHCID 11430Potassium CarbonateHCID 21410009HCID 21410009, compound

Product 1

HCID 21410014HCID 21410014, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium carbonate (7.75 g.) is added to a solution of 15.6 g. of 5-(2-aminoethyl)thiomethyl-4-methylthiazole dihydrochloride in 120 ml. of water. The solution is maintained at ambient temperature for 15 minutes and 5.15 g. of methyl isothiocyanate is added. After refluxing for 1.5 hours, the solution is cooled and the product is collected by filtration to give N-methyl-N'-[2-(4-methyl-5-thiazolylmethylthio)ethyl]-thiourea.

Workup

  1. temperatureAfter refluxing for 1.5 hours
  2. temperaturethe solution is cooled
  3. filtrationthe product is collected by filtration

Sources & evidence

ORD record
ord-8cef595ab1c8479195dd5576135d78f1
Source dataset
uspto-grants-1977_09
Patent number
US04049669

Reaction notes

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