Triethylamine → HCID 86735078, compound

HRID 2072026Notes

Reaction equation

HRID 2072026 reaction equation
Cl[CH:2]([CH2:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([F:21])([F:20])[CH:17]([Cl:19])[Cl:18])=[CH:11][CH:10]=1)(=[O:8])=[O:7])C#N.[CH2:22]([N:24](CC)CC)C>C1C=CC=CC=1>[Cl:19][CH:17]([Cl:18])[C:16]([F:20])([F:21])[O:15][C:12]1[CH:11]=[CH:10][C:9]([S:6]([C:5](=[CH2:2])[C:22]#[N:24])(=[O:7])=[O:8])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 20310058HCID 20310058, compound

Product 1

HCID 86735078HCID 86735078, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 3.0 g (0.079 mol) of 2-chloro-3-((4-(2,2-dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)propanenitrile in 100 ml of benzene was added a slight molar excess of triethylamine. The reaction mixture was filtered to remove the triethylamine hydrochloride produced. The benzene was removed in vacuo from the filtrate, and the residue which remained was crystallized from methanol/ water to give 1.5 g of the title compound as a tan solid, mp 89°-90° C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove the triethylamine hydrochloride
  3. customproduced
  4. customThe benzene was removed in vacuo from the filtrate
  5. customthe residue which remained was crystallized from methanol/ water

Sources & evidence

ORD record
ord-87ae05ab13dc4813a7490c4f1190b628
Source dataset
uspto-grants-1977_09
Patent number
US04049696

Reaction notes

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