Hydrogen Bromide → 1,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

HRID 2072052Notes

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8]O.Cl.[NH2:11][CH2:12][CH2:13][SH:14].C(O)(C)C.CO.[BrH:21]>>[BrH:21].[BrH:21].[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8][S:14][CH2:13][CH2:12][NH2:11]

Participants

Reactant 4

HCID 260Hydrogen Bromide

HCID 9082Cysteamine Hydrochloride

HCID 12923402(1,4-dimethyl-1H-imidazol-2-yl)methanol

HCID 21255859Isopropanol methanol

Product 1

HCID 205579691,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

Procedure

The reaction of 1,4-dimethyl-2-hydroxymethylimidazole (2.5 g) with cysteamine hydrochloride (2.5 g.) in aqueous hydrobromic acid by the method described in Example 1(i)(a) gave 1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (6.2 g.), m.p. 161°-163° (from isopropyl alcohol-methanol).

Sources & evidence

ORD record: ord-72a635fc52fc46709b2b8593af6f7494
Source dataset: uspto-grants-1977_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04049672

Reaction notes

Loading…