Sodium hydride → HCID 21410130, compound

HRID 2072159Notes

Reaction equation

HRID 2072159 reaction equation
CO[C:3]1[CH:18]=[CH:17][C:6]2[CH2:7][CH:8]3[C:14](=[O:15])[C:13](C)([C:5]=2[CH:4]=1)[CH2:12][CH2:11][CH2:10][CH2:9]3.BrCCCC1(C)C2C(=CC=CC=2)CCC1=O.[H-].[Na+]>>[CH3:12][C:13]12[C:14](=[O:15])[CH:8]([CH2:7][C:6]3[CH:17]=[CH:18][CH:3]=[CH:4][C:5]=31)[CH2:9][CH2:10][CH2:11]2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 214101236,7,8,9,10,11-hexahydro-3-methoxy-5-methyl-5,10-methano-5H-benzocyclononen 12-oneHCID 214101501-(3-Bromopropyl)-1-methyl-3,4-dihydronaphthalen-2(1H)-one

Product 1

HCID 21410130HCID 21410130, compound

Procedure

Using a procedure analogous to that described in Example X for the preparation of 6,7,8,9,10,11-hexahydro-3-methoxy-5-methyl-5,10-methano-5H-benzocyclononen-12-one there is otained from 1-(3-bromopropyl)-1-methyl-2-tetralone (4.0 g.) treated with sodium hydride (1 g.); 1.4 g. of the title product, b.p. 122° to 130° C. (0.1 mm.). A sample is converted to the semicarbazone and crystallized from acetonitrile, m.p. 250° to 251° C.

Sources & evidence

ORD record
ord-7181c0551f444d1b9b195f72a4b4047e
Source dataset
uspto-grants-1977_09
Patent number
US04049701

Reaction notes

Loading…