Benzene → oxazolidine, 2,2,4,4-tetramethyl-

HRID 2072210Notes

Reaction equation

HRID 2072210 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[CH:7]1[CH:12]=CC=C[CH:8]=1>CC(C)=O>[CH3:8][C:7]1([CH3:12])[NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][O:4]1

Participants

4

Reactant 2

HCID 241BenzeneHCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 641504oxazolidine, 2,2,4,4-tetramethyl-Yield 57%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Firstly, the precursor compound (2,2,4,4-tetramethyl-1,3-oxazolidine was prepared. To 237 g (3.0 mole) of 2-amino-2-methyl-1 -propanol, there was added approximately 750 ml of dry benzene containing 174 g (3.0 mole) of acetone.

Sources & evidence

ORD record
ord-fdcac0387d4946928981a158481f0d3a
Source dataset
uspto-grants-1977_09
Patent number
US04049818

Reaction notes

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