Hydrochloric Acid → HCID 131710895, compound

HRID 2072217Notes

Reaction equation

HRID 2072217 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH:4]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[O:5][CH2:6][CH2:7][NH:8]C(=O)C.FC1C=CC(C(C2C=CC(F)=CC=2)OCCNC(=O)C)=CC=1.[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].Cl>>[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH:4]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[O:5][CH2:6][CH2:7][NH2:8]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 444266Maleic AcidHCID 21411013HCID 21411013, compoundHCID 21411018HCID 21411018, compound

Product 1

HCID 131710895HCID 131710895, compound

Procedure

Using the procedure described in Example IV but substituting an equivalent amount of N-{2-[o-chloro-α(p-fluorophenyl)benzyloxy]ethyl}acetamide for the N-{2-[bis(p-fluorophenyl)methoxy]ethyl}acetamide and maleic acid for the hydrogen chloride, there is obtained 2-[o-chloro-α-(p-fluorophenyl)benzyloxy]ethylamine hydrogen maleate, which is crystallised from ethanol. Its melting point is 123°-123.5° C.

Sources & evidence

ORD record
ord-17af4646246141aa8bf5af96997024ee
Source dataset
uspto-grants-1977_09
Patent number
US04049825

Reaction notes

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