Hydrochloric Acid → 3p-Phenoxyphenyl-3-hydroxybutyric acid

HRID 2072231Notes

Reaction equation

HRID 2072231 reaction equation
Cl[C:2]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][CH:9]=1)([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].Cl.[O:22](C1C=CC(C(C)=CC(O)=O)=CC=1)C1C=CC=CC=1.[OH-].[K+]>>[O:14]([C:11]1[CH:12]=[CH:13][C:8]([C:2]([OH:22])([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])=[CH:9][CH:10]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54484571HCID 54484571, compoundHCID 70634565HCID 70634565, compound

Product 1

HCID 541805473p-Phenoxyphenyl-3-hydroxybutyric acid

Procedure

1 g. of 3-chloro-3-p-phenoxyphenyl-butyric acid (obtainable by an addition reaction of HCl with 3-p-phenoxyphenyl-2-butenoic acid) and 25 ml. of 20% potassium hydroxide solution are boiled for 10 minutes, cooled, washed with ether and acidified to give 3p-phenoxyphenyl-3-hydroxybutyric acid, m.p. 137°-138°.

Workup

  1. temperaturecooled
  2. washwashed with ether

Sources & evidence

ORD record
ord-d613ec75525d4893aecbd0292e2c16c3
Source dataset
uspto-grants-1977_09
Patent number
US04049823

Reaction notes

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