HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Methoxyestra-2,5(10)-dien-17beta-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Aluminum | HCID 5359268 | — |
| Reactant | 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol | HCID 11055206 | — |
| Reactant | Lithium ethoxide | HCID 23661847 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Methoxyestra-2,5(10)-dien-17beta-ol | HCID 101963 | — |
Reaction Steps
2.0 g. of 3-methoxy-1,3,5(10),8-estratetraen-17β-ol is electrolyzed in 200 ml. of liquid ammonia and 20 ml. of ethanol in the presence of 2 g. of lithium ethylate and 0.5 g. of lithium anilide for 3 hours in an undivided cell between an aluminum cathode and a platinum anode, with a current density of 2.5 A/cm2. After the reaction mixture has been worked up, 1.8 g. of 3-methoxy-2,5(10)-estradien-17β-ol is isolated, m.p. 110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04050998 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-c8055da511c743a99c5b97a5b7660e3c |
| Source note | uspto-grants-1977_09 |