HCID 53720007, compound → HCID 21409186, compound

HRID 2072404Notes

Reaction equation

HRID 2072404 reaction equation
C(OC([N:6]1[C:14]([NH2:15])=[C:13]2[C:8]([CH:9]=[CH:10][CH:11]=[C:12]2[C:16]([F:19])([F:18])[F:17])=[N:7]1)=O)C>C(OC(OC(OCC)=O)=O)C>[NH2:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[C:16]([F:18])([F:17])[F:19])[NH:7][N:6]=1

Participants

3

Reactant 1

HCID 53720007HCID 53720007, compound

Product 1

HCID 21409186HCID 21409186, compound

Reagents, catalysts & solvents 1

HCID 3051Diethyl PyrocarbonateSolvent

Procedure

Analogously to Example 1, 0.06 mol of 3-amino-4-trifluoromethylindazole in 50 ml of pyrocarbonic acid diethyl ester gives 3-amino-4-trifluoromethylindazole-2-carboxylic acid ethyl ester (melting point: 100°-101° C; 85% of theory) in 10 minutes at 20° C.

Sources & evidence

ORD record
ord-b0d278c81d1b488987fa1a7fa43561d6
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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