Diethyl Pyrocarbonate → HCID 21409184, compound

HRID 2072408Notes

Reaction equation

HRID 2072408 reaction equation
C(OC(OC(OCC)=O)=O)C.C(OC([N:17]1[C:25]([NH2:26])=[C:24]2[C:19]([C:20]([N+:31]([O-:33])=[O:32])=[CH:21][C:22]([C:27]([F:30])([F:29])[F:28])=[CH:23]2)=[N:18]1)=O)C>C(O)C>[NH2:26][C:25]1[C:24]2[C:19](=[C:20]([N+:31]([O-:33])=[O:32])[CH:21]=[C:22]([C:27]([F:30])([F:28])[F:29])[CH:23]=2)[NH:18][N:17]=1

Participants

4

Reactant 2

HCID 3051Diethyl PyrocarbonateHCID 53728077HCID 53728077, compound

Product 1

HCID 21409184HCID 21409184, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, 0.1 mol of 3-amino-5-trifluoromethyl-7-nitroindazole and 150 ml of pyrocarbonic acid diethyl ester in 100 ml of ethanol give 3-amino-5-trifluoromethyl-7-nitro indazole-2-carboxylic acid ethyl ester (melting point: 186°-187° C; 74% of theory) in 30 minutes at 80° C.

Sources & evidence

ORD record
ord-7ba037db4d5d4d54bc58bdd12d72455b
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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