HCID 54395129, compound → HCID 21409154, compound

HRID 2072410Notes

Reaction equation

HRID 2072410 reaction equation
C(OC([N:6]1[C:14]([NH2:15])=[C:13]2[C:8]([C:9]([NH:20]C(OCC)=O)=[CH:10][C:11]([C:16]([F:19])([F:18])[F:17])=[CH:12]2)=[N:7]1)=O)C>C(OC(OC(OCC)=O)=O)C>[NH2:15][C:14]1[C:13]2[C:8](=[C:9]([NH2:20])[CH:10]=[C:11]([C:16]([F:18])([F:17])[F:19])[CH:12]=2)[NH:7][N:6]=1

Participants

3

Reactant 1

HCID 54395129HCID 54395129, compound

Product 1

HCID 21409154HCID 21409154, compound

Reagents, catalysts & solvents 1

HCID 3051Diethyl PyrocarbonateSolvent

Procedure

Analogously to Example 1, 0.1 mol of 3,7-diamino-5-trifluoromethylindazole in 70 ml of pyrocarbonic acid diethyl ester gives 3-amino-5-trifluoromethyl-7-ethoxycarbonylaminoindazole-2-carboxylic acid ethyl ester (melting point: 229°-230° C; 89% of theory) in 20 minutes at 70° C.

Sources & evidence

ORD record
ord-600949b557894b9f97f7f4fc6532a218
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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