HCID 53701025, compound → HCID 21409186, compound

HRID 2072411Notes

Reaction equation

HRID 2072411 reaction equation
C(OC([N:6]1[C:14]2[C:9](=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:11]=[CH:12][CH:13]=2)[C:8]([NH2:19])=[N:7]1)=O)C>C(OC(OC(OCC)=O)=O)C>[NH2:19][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:17])([F:16])[F:18])[NH:6][N:7]=1

Participants

3

Reactant 1

HCID 53701025HCID 53701025, compound

Product 1

HCID 21409186HCID 21409186, compound

Reagents, catalysts & solvents 1

HCID 3051Diethyl PyrocarbonateSolvent

Procedure

Analogously to Example 21, 0.06 mol of 3-amino-4-trifluoromethylindazole in 50 ml of pyrocarbonic acid diethyl ester gives 3-amino-4-trifluoromethylindazole-1-carboxylic acid ethyl ester (melting point: 185°-186° C; 68% of theory) in 2 hours at 75° C.

Sources & evidence

ORD record
ord-72aa3d66a6054771a6b12317fc81bec0
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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