HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Amino-6-chloroindazole-2-carboxylic acid dimethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | 6-chloro-1H-indazol-3-amine | HCID 85628 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Amino-6-chloroindazole-2-carboxylic acid dimethylamide | HCID 53709314 | 58% |
Reaction Steps
0.15 mol of dimethylcarbamic acid chloride is added dropwise, while stirring, to 0.1 mol of 3-amino-6-chloroindazole in 50 ml of pyridine, in the course of which the temperature rises to 45° C. After 11/2 hours, 250 ml of water are allowed to run in and the reaction product is isolated by filtration. After dissolving the product in chloroform, filtering off a by-product of melting point 237°-238° C and evaporating the solution, 3-amino-6-chloroindazole-2-carboxylic acid dimethylamide (melting point: 178°-180° C; 58% of theory) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051252 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-7eb222b11d5742848bae9745fa9996a3 |
| Source note | uspto-grants-1977_09 |