反应详情

0.15 mol of dimethylcarbamic acid chloride is added dropwise, while stirring, to 0.1 mol of 3-amino-6-chloroindazole in 50 ml of pyridine, in the course of which the temperature rises to 45° C. After 11/2 hours, 250 ml of water are allowed to run in and the reaction product is isolated by filtration. After dissolving the product in chloroform, filtering off a by-product of melting point 237°-238° C and evaporating the solution, 3-amino-6-chloroindazole-2-carboxylic acid dimethylamide (melting point: 178°-180° C; 58% of theory) is obtained.

1. customrises to 45° C
2. customis isolated by filtration
3. filtrationfiltering off a by-product of melting point 237°-238° C
4. customevaporating the solution