3-Amino-5-trifluoromethylindazole-1-carboxylic acid ethylamide → Ethyl isocyanate

HRID 2072416Notes

Reaction equation

HRID 2072416 reaction equation
[CH2:1]([NH:3][C:4]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:12][CH:13]=2)[C:8]([NH2:19])=[N:7]1)=[O:5])[CH3:2]>N1C=CC=CC=1>[NH2:19][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=2)[NH:6][N:7]=1.[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 539665373-Amino-5-trifluoromethylindazole-1-carboxylic acid ethylamide

Product 2

HCID 8022Ethyl isocyanateHCID 16736Bay-H-1127

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Analogously to Example 46, 0.05 mol of 3-amino-5-trifluoromethylindazole and 0.05 mol of ethyl isocyanate in 100 ml of pyridine give 3-amino-5-trifluoromethylindazole-1-carboxylic acid ethylamide (melting point: 131°-132° C; 47% of theory) in 1 hour at 10°-15° C.

Sources & evidence

ORD record
ord-3c4284e2fa024bf89839ce2124d42c2c
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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