HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | N-(5-(trifluoromethyl)-1H-indazol-3-yl)formamide | HCID 21409159 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide | HCID 53697137 | 57% |
Reaction Steps
0.2 mol of 3-formylamino-5-trifluoromethylindazole and 0.05 mol of dimethylcarbamic acid chloride in 20 ml of pyridine are heated for 4 hours to 50° C. After cooling, 150 ml of water are allowed to run in and the reaction product which has crystallized out is isolated by filtration. Recrystallization from ethanol gives 3formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide (melting point: 198°-200° C; 57% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051252 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-204b62a36e9e4f6490e59b9cf2f417f2 |
| Source note | uspto-grants-1977_09 |