反应详情

A flask was charged with 3-methyl-4-aminophenyl N-methylcarbamate (3.0g., 0.0166 mole), triethylamine (1.83g., 0.018 mole, 2.53 ml.) and about 100 ml. of benzene. To this slurry was added methanesulfonyl chloride and after one hour at reflux the mixture was cooled and filtered. The solids were stirred vigorously with water to dissolve any residual by-product triethylamine hydrochloride. Refiltration and drying gave 2.3g. of the desired product (m.p. 167°-69° C.).

1. temperatureafter one hour at reflux the mixture
2. temperaturewas cooled
3. filtrationfiltered
4. dissolutionto dissolve any residual by-product triethylamine hydrochloride
5. customRefiltration and drying
6. customgave 2.3g