Pyridine → HCID 21409269, compound

HRID 2072423Notes

Reaction equation

HRID 2072423 reaction equation
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].[CH3:7][NH:8][C:9](=[O:19])[O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH3:18])[CH:12]=1.N1C=CC=CC=1>O>[CH3:7][NH:8][C:9](=[O:19])[O:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[C:13]([CH3:18])[CH:12]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 11667Ethanesulfonyl chlorideHCID 25072Aminomatacil

Product 1

HCID 21409269HCID 21409269, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethanesulfonyl chloride (2.2g., 0.0171 mole) was added dropwise to a stirred solution of 3-methyl-4-aminophenyl N-methylcarbamate (3.0g., 0.0166 mole) in 20 ml. of pyridine. The temperature rose to a maximum of 38° C. and then subsided. Stirring was continued at ambient temperature for one hour, and the reaction mixture poured into excess water to give an insoluble precipitate. Recrystallization from ethanol-water gave the product as a beige powder, m.p. 146.5°-48.5° C.

Workup

  1. customrose to a maximum of 38° C.
  2. customto give an insoluble precipitate
  3. customRecrystallization from ethanol-water

Sources & evidence

ORD record
ord-629868fa63324381b5702058bef79561
Source dataset
uspto-grants-1977_09
Patent number
US04051254

Reaction notes

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