反应详情

p-Toluenesulfonyl chloride (2.1g., 0.011 mole) was added portionwise to a solution of 3-methyl-4-aminophenyl N-methylcarbamate (1.8g., 0.01 mole) in pyridine (15 ml.). An exotherm to about 45° C. resulted and warming was continued at 48° C. for a short time. An excess of water was added and upon stirring and cooling, the product crystallized. The filtered product (3.1g.) was recrystallized from ethanol/water to give material with m.p. 181°-83.5° C.

1. customAn exotherm to about 45° C. resulted
2. temperaturewarming
3. customwas continued at 48° C. for a short time
4. temperaturecooling
5. customthe product crystallized
6. customThe filtered product (3.1g.) was recrystallized from ethanol/water
7. customto give material with m.p. 181°-83.5° C.