反应详情

A mixture of 20.0 grams (0.0785 mole) of α-bromo-p-pivaloyl toluene, 30.0 grams (0.157 mole) of potassium acetate and 60 milliliters of glacial acetic acid is refluxed for 20 hours. The acetic acid is removed in vacuo, and the residue is treated with ice water and then extracted with methylene chloride. The methylene chloride extract is washed with 2N sodium hydroxide solution, dried with magnesium suflate, and then filtered and evaporated to give α-acetoxy-p-pivaloyl toluene.

1. temperatureis refluxed for 20 hours
2. customThe acetic acid is removed in vacuo
3. additionthe residue is treated with ice water
4. extractionextracted with methylene chloride
5. extractionThe methylene chloride extract
6. washis washed with 2N sodium hydroxide solution
7. dry with materialdried with magnesium suflate
8. filtrationfiltered
9. customevaporated