Potassium Acetate → HCID 21409404, compound

HRID 2072452Notes

Reaction equation

HRID 2072452 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:5][CH:4]=1.[C:15]([O-:18])(=[O:17])[CH3:16].[K+]>C(O)(=O)C>[C:15]([O:18][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:5][CH:4]=1)(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 128310071-[4-(Bromomethyl)phenyl]-2,2-dimethylpropan-1-one

Product 1

HCID 21409404HCID 21409404, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 20.0 grams (0.0785 mole) of α-bromo-p-pivaloyl toluene, 30.0 grams (0.157 mole) of potassium acetate and 60 milliliters of glacial acetic acid is refluxed for 20 hours. The acetic acid is removed in vacuo, and the residue is treated with ice water and then extracted with methylene chloride. The methylene chloride extract is washed with 2N sodium hydroxide solution, dried with magnesium suflate, and then filtered and evaporated to give α-acetoxy-p-pivaloyl toluene.

Workup

  1. temperatureis refluxed for 20 hours
  2. customThe acetic acid is removed in vacuo
  3. additionthe residue is treated with ice water
  4. extractionextracted with methylene chloride
  5. extractionThe methylene chloride extract
  6. washis washed with 2N sodium hydroxide solution
  7. dry with materialdried with magnesium suflate
  8. filtrationfiltered
  9. customevaporated

Sources & evidence

ORD record
ord-d83fde2ef4b046918b3791c80a1d7c69
Source dataset
uspto-grants-1977_09
Patent number
US04051261

Reaction notes

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