Hydrochloric Acid → 1-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]-decan-4-one, hydrochloride

Participants

Reaction Steps

1-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (3.7 g) is suspended in absolute ethanol (100 ml) and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is then digested on a steam bath for 10 minutes, cooled in an ice-bath, and filtered to yield 3.7 g of the title compound, melting point 248°-249° C.

Provenance & Evidence