Hydrochloric Acid → 1-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]-decan-4-one, hydrochloride

HRID 2072458Notes

Reaction equation

HRID 2072458 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[C@H:19]4[OH:28])[CH2:13][CH2:12]3)[C:10](=[O:29])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:30]>C(O)C>[ClH:30].[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[C@H:19]4[OH:28])[CH2:13][CH2:12]3)[C:10](=[O:29])[NH:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22799508HCID 22799508, compound

Product 1

HCID 1317109011-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]-decan-4-one, hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (3.7 g) is suspended in absolute ethanol (100 ml) and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is then digested on a steam bath for 10 minutes, cooled in an ice-bath, and filtered to yield 3.7 g of the title compound, melting point 248°-249° C.

Workup

  1. temperaturecooled in an ice-bath
  2. filtrationfiltered

Sources & evidence

ORD record
ord-a7a2712f76f4434cac0395dd52f903cb
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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