Hydrochloric Acid → HCID 131710903, compound

Participants

Reaction Conditions

Reaction Steps

1-Phenyl-8-[(1,2,3,4-tetrahydro-6-methoxy-1-oxo-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (6.0 g) is finely ground and slurried in absolute ethanol (200 ml). While cooling the mixture at 0° C, ethanolic hydrogen chloride solution (1 equivalent) is added dropwise. The resulting mixture is stirred at room temperature for 15 minutes, heated on a steam bath for 10 minutes and allowed to stand at room temperature for 2 hours. The solid product is collected, washed with absolute ethanol, and dried under vacuum to yield 5.2 g of the title compound, melting point 203°-204° C.

Provenance & Evidence