Hydrochloric Acid → HCID 131710903, compound

HRID 2072461Notes

Reaction equation

HRID 2072461 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][CH:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C:19]4=[O:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>C(O)C>[ClH:32].[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][CH:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C:19]4=[O:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21408205HCID 21408205, compound

Product 1

HCID 131710903HCID 131710903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

1-Phenyl-8-[(1,2,3,4-tetrahydro-6-methoxy-1-oxo-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (6.0 g) is finely ground and slurried in absolute ethanol (200 ml). While cooling the mixture at 0° C, ethanolic hydrogen chloride solution (1 equivalent) is added dropwise. The resulting mixture is stirred at room temperature for 15 minutes, heated on a steam bath for 10 minutes and allowed to stand at room temperature for 2 hours. The solid product is collected, washed with absolute ethanol, and dried under vacuum to yield 5.2 g of the title compound, melting point 203°-204° C.

Workup

  1. temperatureheated on a steam bath for 10 minutes
  2. waitto stand at room temperature for 2 hours
  3. customThe solid product is collected
  4. washwashed with absolute ethanol
  5. customdried under vacuum

Sources & evidence

ORD record
ord-5c2e602023ee4980a76509b65dde27b9
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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